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Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation
Raoul Poupon1,2
1UPMC University of Paris 06, INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.
Hepatology (Baltimore, Md.)
|January 22, 2015
Summary
Serum alkaline phosphatase (AP) indicates cholestasis severity. Restoring liver AP activity may treat inflammatory bile duct diseases like primary biliary cirrhosis and primary sclerosing cholangitis.
Area of Science:
- Hepatology
- Biochemistry
- Gastroenterology
Background:
- Serum alkaline phosphatase (AP) is a marker for cholestasis and fibrosing cholangiopathies.
- Its role in liver health and disease is under investigation.
Purpose of the Study:
- To review the role of liver AP in health and cholestatic diseases.
- To discuss potential therapeutic strategies targeting AP in fibrosing cholangiopathies.
Main Methods:
- Literature review and opinion article.
- Discussion of biochemical and cellular mechanisms.
- Exploration of therapeutic interventions.
Main Results:
- Loss of liver AP activity in cholestasis may promote inflammation via hyper-adenosine triphosphate-bilia and lipopolysaccharide overload.
- Restoring hepatocyte polarity and bile acid export is crucial.
Conclusions:
- Targeting liver AP and bile acid metabolism may offer therapeutic benefits for primary biliary cirrhosis and primary sclerosing cholangitis.
- Oral intestinal AP warrants further investigation as a therapeutic approach.
- The liver microenvironment significantly influences inflammatory processes in fibrosing cholangiopathies.
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