[Correlation between thyroid hormones and renal function in severe pre-eclampsia patients with hypothyroidism]

Area of Science:

• Obstetrics and Gynecology
• Endocrinology
• Nephrology

Background:

• Severe pre-eclampsia (S-PE) is a serious pregnancy complication.
• Thyroid dysfunction, including hypothyroidism, can coexist with S-PE.
• The impact of different degrees of hypothyroidism on renal function in S-PE is not fully understood.

Purpose of the Study:

• To investigate the effects of subclinical hypothyroidism (SCH) and overt hypothyroidism (OH) on renal function in S-PE pregnant women.
• To explore the correlation between thyroid hormone levels and renal function markers in S-PE.

Main Methods:

• A comparative study involving 46 S-PE patients with SCH, 23 with OH, and 109 with normal thyroid function (simple S-PE group).
• Analysis of thyroid hormones (TSH, FT3, FT4) and renal function markers (serum uric acid, urea, creatinine).
• Statistical analysis to compare renal function between groups and assess correlations.

Main Results:

• S-PE patients with OH exhibited significantly higher serum uric acid, urea, and creatinine levels compared to the simple S-PE group.
• The abnormal detection rate of serum uric acid was significantly higher in the SCH group than in the OH group.
• A negative correlation was observed between free triiodothyronine (FT3) and serum creatinine in S-PE patients, particularly in the OH group.

Conclusions:

• Different degrees of hypothyroidism significantly affect renal function in S-PE patients.
• OH is associated with poorer renal function markers in S-PE.
• Regular thyroid function monitoring is crucial for early detection of renal impairment in S-PE.