Related Experiment Video
Updated: Apr 18, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Renal and metabolic effects of valsartan
1Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, İstanbul Bilim University; İstanbul-Turkey. tevfikecder@yahoo.com.
Abstract:
It is known that the drugs which suppress the renin-angiotensin-aldosterone system can prevent target organ damage, independent of their blood pressure lowering effects. Besides, it has been reported that this group of drugs has positive metabolic effects. There are many studies showing that valsartan, being an angiotensin receptor blocker and widely used in hypertension treatment, has cardioprotective and renoprotective effects in high risk patients. It has been seen in these studies that, valsartan treatment has a decreasing effect on proteinuria, independent of its blood pressure lowering effects in the patients having either diabetic and non-diabetic nephropathy. In this review, the studies investigating the renal effects of valsartan will be mentioned. Additionally, the studies about the metabolic effects of valsartan will be reported.
More Related Videos
Related Concept Videos
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Direct Renin Inhibitors
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Heart Failure Drugs: Diuretics

