Related Experiment Video
Updated: Apr 18, 2026
09:10
Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
Published on: December 16, 2013
6.5K
Innate lymphoid cells involve in tumorigenesis.
Zhiqiang Tian1, Jennifer C van Velkinburgh2, Yuzhang Wu1
1Institute of Immunology PLA, Third Military Medical University, Chongqing, China.
International Journal of Cancer
|January 22, 2015
Summary
Innate lymphoid cells (ILCs) are crucial for immune responses and anti-tumor functions. This review explores their role in tumorigenesis and potential as targets for cancer intervention.
Area of Science:
- Immunology
- Cancer Biology
Background:
- Innate lymphoid cells (ILCs) are key players in mucosal immunity and pathogen response.
- ILCs are classified into three distinct groups within the lymphoid lineage.
- Recent findings highlight ILCs' involvement in anti-tumor immunity.
Purpose of the Study:
- To review the involvement of ILCs in tumorigenesis.
- To elucidate the mechanisms underlying ILC functions in cancer.
- To identify potential therapeutic targets for tumor intervention.
Main Methods:
- Literature review of ILCs' role in immunity and cancer.
- Analysis of ILC classification and functions.
- Discussion of ILCs' impact on tumorigenesis.
Main Results:
- ILCs are involved in both promoting and suppressing tumor development.
- Specific ILC groups exhibit distinct roles in the tumor microenvironment.
- ILCs influence anti-tumor immune responses.
Conclusions:
- ILCs represent a promising target for novel cancer therapies.
- Understanding ILC mechanisms can lead to improved tumor intervention strategies.
- Further research into ILCs' dual role in cancer is warranted.
Related Concept Videos
01:18Lymphoid Cells and Tissues
4.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
4.0K
01:23Cells of the Adaptive Immune Response
10.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.3K
01:16Primary Lymphoid Organs
17.0K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
17.0K
02:21Cancers Originate from Somatic Mutations in a Single Cell
15.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.9K
02:21Cancers Originate from Somatic Mutations in a Single Cell
3.6K
3.6K
01:15Secondary Lymphoid Organs
10.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.6K