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Changes in thyroid function with age: results from the Pizarra population-based longitudinal study.

A Ma Lago-Sampedro¹, C Gutiérrez-Repiso, S Valdés

¹Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigaciones Biomédicas de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIII, Málaga, Spain.

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Summary

This summary is machine-generated.

Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels naturally increase over time in adults without thyroid disease. This age-related thyroid function change is more pronounced in individuals with higher baseline TSH and FT4 levels.

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Area of Science:

Endocrinology
Gerontology
Thyroid Research

Background:

Controversy exists regarding the influence of aging on thyroid function and TSH levels in euthyroid individuals.
Longitudinal data on thyroid function changes over time in a healthy population is limited.

Purpose of the Study:

To investigate the 11-year course of thyroid function in a population with normal baseline thyroid function.
To determine if thyroid function parameters change with age in the absence of thyroid disease.

Main Methods:

A population-based prospective study was conducted.
Participants were assessed at baseline (1995-1997), after 6 years, and after 11 years.

Main Results:

Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels significantly increased over the 11-year study period (p=0.001 for both).
The rise in TSH and FT4 was particularly notable from age 50 onwards.
Individuals with higher baseline TSH levels showed a significantly increased odds of having elevated TSH levels at follow-up.

Conclusions:

In individuals without clinical thyroid disease, TSH and FT4 levels tend to increase over time.
This age-related increase in thyroid function parameters is observed across all age groups but is primarily influenced by baseline TSH and FT4 concentrations.