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Fibroblast growth factor 19-targeted therapies for the treatment of metabolic disease

Jacek Rysz1, Anna Gluba-Brzózka, Dimitri P Mikhailidis

  • 1WAM University Hospital of Lodz, Department of Nephrology, Hypertension and Family Medicine , Zeromskiego 113, 90-549 Lodz , Poland +48 42 639 37 50 ; +48 42 639 37 50 ; jacek.rysz@umed.lodz.pl.

Expert Opinion on Investigational Drugs
|January 22, 2015
PubMed
Abstract

Insights

Fibroblast growth factor 19 (FGF19) shows promise for treating metabolic disorders like diabetes by reducing liver fat and improving glucose control. While animal studies are encouraging, human trials are needed to confirm its therapeutic potential.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Molecular Biology

Background:

  • Fibroblast growth factors (FGFs) are a superfamily with diverse biological roles.
  • FGF19 demonstrates potential in reducing liver fat, triglycerides, cholesterol, and plasma glucose.
  • FGF19 also improves insulin sensitivity and regulates bile acid, glucose, vitamin D, and phosphate homeostasis.

Purpose of the Study:

  • To highlight the metabolic effects and mechanism of action of FGF19.
  • To discuss potential FGF19-targeting therapies.
  • To review the therapeutic potential of FGF19 for metabolic disorders.

Main Methods:

  • Review of existing literature on FGF19's metabolic effects.
  • Analysis of FGF19's mechanism of action.
  • Discussion of FGF19-based therapeutic strategies.

Main Results:

  • FGF19 reduces liver fat, triglycerides, total cholesterol, and plasma glucose.
  • FGF19 ameliorates diabetes in animal models by increasing metabolic rate and reducing body weight.
  • FGF19 regulates key metabolic pathways including bile acid biosynthesis and glucose metabolism.

Conclusions:

  • FGF19 is an emerging therapeutic target for metabolic disorders, particularly diabetes.
  • Promising results from animal models suggest significant therapeutic potential.
  • Further research and human clinical trials are necessary for practical application.
Keywords:
animal modelsfibroblast growth factor 19metabolic syndrometreatment

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