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The unexpected increase of clotrimazole apparent solubility using randomly methylated β-cyclodextrin

Bénédicte Pradines1, Jean-François Gallard, Bogdan I Iorga

  • 1Institut Galien Paris Sud, UMR CNRS 8612, Université Paris-Sud, Faculté de Pharmacie, 5, rue J-B. Clément, 92296, Chatenay-Malabry cedex, France; BioCis, Biomolécules : conception, isolement, synthèse-Chimiothérapie Antiparasitaire, UMR CNRS 8076, Université Paris-Sud, Faculté de Pharmacie, 5, rue J-B. Clément, 92296, Châtenay-Malabry cedex, France.

Journal of Molecular Recognition : JMR
|January 22, 2015
PubMed
Summary

Randomly-methylated β-cyclodextrin significantly enhances clotrimazole solubility by over 9980 times, offering a novel approach for drug formulation. This breakthrough surpasses previous cyclodextrin-based solubility improvements for clotrimazole.

Keywords:
bidimensionnal 1H-RMNclotrimazolecyclodextrinsmolecular dockingsolubilization

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