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Updated: Apr 18, 2026

Fluorescent Silver Staining of Proteins in Polyacrylamide Gels
Published on: April 21, 2019
i-Motif-modulated fluorescence detection of silver(I) with an ultrahigh specificity
Yunhua Shi1, Hongxia Sun2, Junfeng Xiang2
1National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China; Graduate University of the Chinese Academy of Sciences, Yuquan Road 19(A), Shijingshan District, Beijing 100049, PR China.
Abstract:
A novel Ag(+) sensor has been designed based on the mechanism that i-motif formation induced by Ag(+) was sensitively recognized by a cyanine dye. The sensor exhibited an over 130-16,000 fold selectivity toward Ag(+) than that toward other metal ions. This research not only provides a step forward toward the development of Ag(+) detection but also represents a new application for i-motif DNA.
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