[Angiotensin converting enzyme in the blood and lungs in experimental diabetes]

The activity of angiotensin converting enzyme has been examined in serum and lungs of Wistar male rats with streptozotocin induced diabetes. The diabetes has been induced by single i.v. dose of streptozotocin (75 mg/kg body weight). The activity of angiotensin converting enzyme in serum and lungs has been measured ten days after application of drug by spectrophotometrical method using synthetic substrate hippuryl-1-histidyl-1-leucine. The results show that streptozotocin induced diabetes in rats cause significant increase in angiotensin converting enzyme activity in serum and lungs.