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Updated: Apr 18, 2026
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
In vitro susceptibility testing of eravacycline is unaffected by medium age and nonstandard assay parameters
Trudy H Grossman1, Chris M Pillar2, Daniel F Sahm2
1Tetraphase Pharmaceuticals, Watertown, Massachusetts, USA tgrossman@tphase.com.
Abstract:
Eravacycline is a fluorocycline antibiotic in phase 3 clinical development for complicated intra-abdominal and urinary tract infections. To support its clinical development, a study was conducted to evaluate the effects of various susceptibility test parameters on the MIC values for aerobic bacteria. The results showed that eravacycline appears to be largely unaffected by medium age, medium additives, and other nonstandard assay conditions.
