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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Interaction between VWF and FVIII in treating VWD

Wolfgang Miesbach1, Erik Berntorp2

  • 1Medical Clinic III, Institute of Transfusion Medicine, Goethe University, Frankfurt, Germany.

European Journal of Haematology
|January 22, 2015
PubMed

In patients with von Willebrand disease (VWD), the absence of von Willebrand factor (VWF) antigen leads to the premature loss of endogenous circulating secreted factor VIII (FVIII), thereby resulting in the dual defect in haemostasis. Consequently, correcting the VWF deficiency also acts to correct the associated defect in FVIII activity because exogenous VWF forms complexes with and protects endogenous FVIII. The purpose of this study was to summarise relevant aspects of the interaction between VWF and FVIII and to analyse their effects on VWD treatment. Differences in the VWF/FVIII ratios in coagulation factor concentrates should be considered when treating VWD.

Keywords:
factor VIIIhaemophilia Avon Willebrand diseasevon Willebrand factor

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