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Molecular species of the antitumor and antiviral fraction from pine cone extract
H Sakagami1, T Oh-Hara, T Kaiya
1First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Abstract:
The most active fraction (Fr. VI) of antitumor and antiviral pine cone extract was subjected to chemical structure analysis. IR, UV, and ESR spectroscopies, in addition to chromatographic analysis on cellulose-TLC plates, reveal that the major component of Fr. VI includes structures belonging to the lignin family. A commercial alkali-lignin showed antiviral activity and granulocyte iodination stimulating activity as effective as those of Fr. VI, but had much weaker immunopotentiating activities, such as antitumor and antimicrobial activities and splenocyte stimulating activity. As a tentative conclusion, the active principle of Fr. VI might be complex(s) of lignin-like polyphenolic skeleton with a molecular matrix of unknown components.