Related Experiment Video

Updated: Apr 18, 2026

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.9K

Photothrombosis of corneal neovascularization by photodynamic therapy utilizing verteporfin and diode laser

Aziza Ahmed Hassan1, Dina Foad Ghoneim1, Amr Abdelraheem El-Dib1

  • 1Ophthalmic Department, National Institute of Laser Enhanced Science, Cairo University, Egypt.

Journal of Lasers in Medical Sciences
|January 22, 2015
PubMed
Abstract

Insights

Photodynamic therapy (PDT) using Verteporfin effectively treated experimental corneal neovascularization in rabbits. Clinical and histopathological results showed significant regression of new blood vessels after treatment.

Area of Science:

  • Ophthalmology
  • Photodynamic Therapy
  • Vascular Biology

Background:

  • Corneal neovascularization (NV) poses a significant challenge in ophthalmology.
  • Benzoporphyrin derivative (BPD) has shown potential in therapeutic applications.

Purpose of the Study:

  • To evaluate the efficacy of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for experimental corneal neovascularization.

Main Methods:

  • Corneal NV was induced in New Zealand male rabbits using silk sutures.
  • Treatment involved intravenous injection of Verteporfin followed by diode laser (660 nm) application.
  • Corneal changes were monitored via slit lamp examination and histopathological analysis over 4 weeks.

Main Results:

  • Photodynamic therapy (PDT) demonstrated gradual regression of corneal neovascularization over 4 weeks.
  • Clinical assessment revealed a decrease in the number and length of corneal blood vessels.
  • Histopathological examination confirmed the regression of neovascularization.

Conclusions:

  • Photodynamic therapy (PDT) with Verteporfin is an efficacious treatment for experimental corneal neovascularization.
  • PDT offers a promising therapeutic strategy for managing corneal vascular disorders.
Keywords:
corneal neovascularizationsdiode laserphotodynamic therapy

More Related Videos

An “All-laser” Endothelial Transplant09:59

An “All-laser” Endothelial Transplant

Published on: July 6, 2015

10.1K
Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation04:43

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation

Published on: May 23, 2025

1.0K

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
8
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.7K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K