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The relationship between apolipoprotein CIII gene polymorphism and serum lipid levels in Han Chinese males

Shu Su1, Min Tang2, Mingjun Zhang3

  • 1School of Public Health and Management, Chongqing Medical University, Chongqing, China ; Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.

Meta Gene
|January 22, 2015
PubMed

Insights

Apolipoprotein CIII gene polymorphisms, specifically apoCIII(3175) GG, predict higher triglyceride levels in Han Chinese males. The apoCIII(3206)G variant may help lower serum lipids.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Population Health Studies

Background:

  • Apolipoprotein CIII (apoCIII) gene polymorphisms are linked to serum lipid levels, but findings vary across populations.
  • Previous research has not extensively examined apoCIII's impact on serum lipids in Han Chinese males.

Purpose of the Study:

  • To investigate the association between apoCIII gene polymorphisms (C3175G and T3206G) and serum lipid profiles in Han Chinese males.
  • To identify potential genetic risk factors for hyperlipidaemia within this specific demographic.

Main Methods:

  • A cohort of 337 healthy Han Chinese males from Chongqing, China, was recruited.
  • DNA sequencing was employed to identify apoCIII gene C3175G and T3206G polymorphisms.
  • Statistical analyses were performed to correlate genotypes with serum lipid levels (TG, TC, LDL-C).

Main Results:

  • Carriers of the apoCIII(3175) GG genotype exhibited significantly higher triglyceride (TG) levels.
  • The apoCIII(3206)G allele was associated with reduced total cholesterol (TC) and LDL-C in individuals with high TG.
  • Logistic regression indicated that the apoCIII(3206)G polymorphism is beneficial for lowering TG levels.

Conclusions:

  • The apoCIII(3175) GG genotype serves as an effective predictor for hypertriglyceridaemia in Han Chinese males.
  • The apoCIII(3206)G gene variant shows potential benefits in reducing serum lipid levels.
Abstract

Keywords:
ANOVA, Analysis of varianceApoCIII geneApoCIII, Apolipoprotein CIIIBMI, Physique indexHDL-C, High density lipoprotein-cholesterolHTG, HypertriglyceridaemiaIR, Insulin resistanceLDL-C, Low density lipoprotein-cholesterolPolymorphismSerum lipidsTC, Total cholesterolTG, TriacylglycerolTRL, Triglyceride-rich lipoproteinWHR, Waist to hip ratio

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