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Related Experiment Videos

Developmentally regulated expression of specific tau sequences.

K S Kosik1, L D Orecchio, S Bakalis

  • 1Department of Neurology (Neuroscience), Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.

Neuron
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

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Researchers identified a novel tau protein sequence variant during early brain development. This immature tau mRNA form declines after birth, but reappears in Alzheimer's disease.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Tau protein is crucial for microtubule stability.
  • Tau protein undergoes developmental changes in molecular mass and complexity.
  • Tau is implicated in neurodegenerative diseases like Alzheimer's.

Purpose of the Study:

  • To characterize the molecular changes in tau protein during early postnatal development.
  • To identify novel tau protein sequences and their developmental expression patterns.
  • To compare developmentally expressed tau sequences with those found in Alzheimer's disease.

Main Methods:

  • Sequencing of tau cDNA from adult rat brain expression library.
  • Oligonucleotide probe hybridization to detect tau mRNA expression.

Related Experiment Videos

  • Analysis of tau mRNA expression across different developmental time points (embryonic to postnatal).
  • Comparison of developmental tau sequences with those from Alzheimer's paired helical filaments.

    • Main Results:

    • Two inserted sequences were found in adult rat brain tau cDNA, one predicting a fourth microtubule-binding repeat.
    • An immature tau mRNA form, lacking the insert, is expressed from embryonic day 14 to postnatal day 8, then declines.
    • A mature tau mRNA form containing the insert is expressed postnatally.
    • Both mature and immature tau mRNA sequences were detected in Alzheimer's paired helical filaments.

    Conclusions:

    • A novel, immature tau mRNA sequence is developmentally regulated during early postnatal brain development.
    • This immature tau mRNA form reappears in the context of Alzheimer's disease pathology.
    • Understanding these developmental tau isoforms may provide insights into Alzheimer's disease mechanisms.