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Updated: Apr 18, 2026
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
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Chromatin Memory in the Development of Human Cancers
Yixin Yao1, Thomas L Des Marais1, Max Costa2
1Department of Environmental Medicine New York University, New York, USA.
Gene Technology
|January 22, 2015
Summary
Epigenetic alterations, like changes in histone modification, are hallmarks of cancer. Understanding these changes, particularly chromatin remodeling, offers insights into cancer development and potential therapeutic targets.
Area of Science:
- Oncology
- Epigenetics
- Molecular Biology
Background:
- Cancer is characterized by genomic and epigenomic alterations impacting cell behavior.
- Epigenetic mechanisms such as DNA methylation and histone modification are implicated in carcinogenesis.
- Altered histone modifications are a frequent hallmark observed in tumors.
Purpose of the Study:
- To review the role of chromatin remodeling and histone modifiers in cancer development.
- To discuss the therapeutic potential of targeting these modifiers in cancer treatment.
Main Methods:
- Literature review focusing on chromatin remodeling and histone modifiers in cancer.
- Analysis of epigenetic alterations induced by carcinogens and infectious agents.
- Examination of clinical trial data for histone modifier-targeted therapies.
Main Results:
- Epigenetic mechanisms are closely associated with carcinogenesis and cancer-specific expression profiles.
- Chromatin remodeling plays a significant role in cancer progression.
- Histone modifiers are emerging as promising therapeutic targets in various clinical trials.
Conclusions:
- Understanding epigenetic changes, especially in chromatin remodeling, is crucial for deciphering early cancer development.
- Targeting histone modifiers represents a viable strategy for novel cancer therapies.
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