Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibiotics stimulate protein transfer to persister cells.

Science (New York, N.Y.)·2026
Same author

Ion-triggered reconfigurable hydrogels with salt-enhanced mechanical and swelling properties via network topological adaptation.

Nature communications·2026
Same author

Implantable living materials autonomously deliver therapeutics using contained engineered bacteria.

Science (New York, N.Y.)·2026
Same author

Rapid fabrication of solvent-compatible NOA 81 microfluidic devices for double-emulsion microfluidics.

Lab on a chip·2026
Same author

Green Oil-in-Water Nanoemulsions for Delivery of Phytochemicals With Pesticidal Activity for Sustainable Food Production and Safety.

Comprehensive reviews in food science and food safety·2026
Same author

Mechanical performance of hybrid polymer-lipid vesicles with leaflet asymmetry engineered using microfluidics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

Blood·2026
Same journal

Identifying steroid-refractory aGVHD before it happens.

Blood·2026
Same journal

ELISA-negative HIT: antibody recognition and relevance.

Blood·2026
Same journal

EBV and immunodeficiency: the odd couple drawn to the brain.

Blood·2026
Same journal

A bone to pick with ferric carboxymaltose.

Blood·2026
Same journal

A step toward streamlining HIT diagnosis.

Blood·2026
See all related articles

Related Experiment Video

Updated: Apr 18, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.6K

Platelet bioreactor-on-a-chip.

Jonathan N Thon, Linas Mazutis, Stephen Wu

    Blood
    |January 22, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Researchers created a microfluidic bioreactor to produce functional platelets, addressing shortages and risks associated with human donor platelets for transfusions.

    More Related Videos

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
    10:25

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

    Published on: March 19, 2016

    10.1K
    Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors
    12:39

    Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors

    Published on: May 21, 2008

    12.2K

    Related Experiment Videos

    Last Updated: Apr 18, 2026

    A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
    09:38

    A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

    Published on: February 14, 2017

    14.6K
    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
    10:25

    Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

    Published on: March 19, 2016

    10.1K
    Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors
    12:39

    Chip-based Three-dimensional Cell Culture in Perfused Micro-bioreactors

    Published on: May 21, 2008

    12.2K

    Area of Science:

    • Biomedical Engineering
    • Hematology
    • Regenerative Medicine

    Background:

    • Platelet transfusions are critical but face shortages and risks like sepsis and immunogenicity.
    • Current platelet supply relies solely on human donors, with a limited 5-day shelf life.

    Purpose of the Study:

    • To develop an in vitro system for producing functional human platelets.
    • To mimic the bone marrow microenvironment to stimulate platelet production.

    Main Methods:

    • Engineered a microfluidic bioreactor simulating bone marrow stiffness, ECM, micro-channel size, and shear stress.
    • Incorporated endothelial cell contacts to replicate vascular interactions.
    • Utilized live-cell microscopy for real-time monitoring and quantification of platelet production.

    Main Results:

    • Physiological shear stresses initiated proplatelet formation.
    • Successfully reproduced ex vivo bone marrow proplatelet production.
    • Generated functional platelets in a controlled, in vitro environment.

    Conclusions:

    • The microfluidic bioreactor effectively models human thrombopoiesis.
    • This technology offers a potential solution to platelet shortages and transfusion risks.
    • In vitro platelet production can meet growing transfusion demands safely and efficiently.