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Published on: March 1, 2024
Assessment of cardiovascular risk in patients with moderate to severe plaque psoriasis
Insights
Patients with moderate to severe psoriasis have a higher 10-year cardiovascular risk compared to those with other skin conditions. Early detection and management of cardiovascular risk factors are crucial for psoriasis patients.
Area of Science:
- Dermatology
- Cardiology
- Public Health
Background:
- Psoriasis is linked to increased cardiovascular morbidity and mortality.
- Assessing 10-year cardiovascular risk in psoriasis patients is critical.
Purpose of the Study:
- To compare the 10-year cardiovascular risk between moderate to severe psoriasis patients and those with other dermatological diseases.
- To utilize the Framingham risk score and Systematic Coronary Risk Evaluation (SCORE) charts for risk assessment.
Main Methods:
- A cross-sectional, multicentre study involved 477 patients.
- 238 patients had moderate to severe psoriasis (cases), and 239 had other dermatological diseases (controls).
Main Results:
- Psoriasis patients showed a significantly higher intermediate to high 10-year cardiovascular risk (38.5%) by Framingham score compared to controls (23.4%).
- No significant difference in cardiovascular risk was found using SCORE charts.
- Psoriasis patients had higher rates of obesity and unfavorable lipid profiles (triglycerides, LDL cholesterol).
Conclusions:
- Moderate to severe psoriasis is associated with a greater cardiovascular risk than other dermatological conditions.
- Early identification and personalized management of cardiovascular risk factors are essential for psoriasis patients to reduce morbidity.
Background:
Cardiovascular morbidity and mortality have been demonstrated to be greater in psoriasis patients than in the general population. Our study aimed to assess the 10-year cardiovascular risk in patients with moderate to severe psoriasis compared with those suffering from other dermatological diseases, using the calibrated Framingham risk score and the Systematic Coronary Risk Evaluation (SCORE) risk charts.
Methods:
A cross-sectional, multicentre study was made of 477 patients, of whom 238 had moderate to severe psoriasis (cases) and 239 were diagnosed with another dermatological disease (controls).
Results:
The proportion of patients with intermediate to high 10-year cardiovascular risk using the Framingham equation was significantly higher among psoriasis patients (38.5%; 80/208) than among the controls with other dermatological diseases (23.4%; 50/214, P<.05). No significant differences were observed between the 2 groups with respect to cardiovascular risk using the SCORE risk charts (P=.591). The case group included a greater proportion of obese and morbidly obese patients, as well as patients with higher triglyceride and low density lipoprotein cholesterol levels (P<.05); while high density lipoprotein cholesterol levels were significantly more favorable in patients in the control group (P<.05).
Conclusions:
Cardiovascular risk was greater in patients with moderate to severe psoriasis than in patients with other dermatological conditions, suggesting that early detection and tailored management of risk factors is essential to reducing cardiovascular morbidity in these patients.
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