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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
12.2K
Pluronic copolymer encapsulated SCR7 as a potential anticancer agent
Franklin John1, Jinu George, Mrinal Srivastava
1Biotechnology Laboratory, PG and Research Department of Chemistry, Sacred Heart College, Kochi 682 013, India. franklinshc@gmail.com.
Faraday Discussions
|January 22, 2015
Summary
Polymer encapsulation enhances the bioavailability of SCR7, an anticancer compound that inhibits DNA repair. This formulation improves SCR7
Area of Science:
- Molecular Biology
- Biochemistry
- Drug Delivery
Background:
- Nonhomologous end joining (NHEJ) is a critical DNA repair pathway.
- SCR7 inhibits NHEJ and shows anticancer potential.
- SCR7's hydrophobicity limits its therapeutic bioavailability.
Purpose of the Study:
- To improve the bioavailability of SCR7 for therapeutic applications.
- To develop a polymer-encapsulated formulation of SCR7.
Main Methods:
- Preparation of SCR7-loaded Pluronic® copolymer nanoparticles.
- Characterization of SCR7-copolymer physical interaction using analytical techniques.
- In vitro cytotoxicity assessment of SCR7 formulations via MTT assay.
Main Results:
- Evidence of physical interaction between SCR7 and Pluronic® copolymer.
- Demonstrated in vitro cytotoxicity of the developed SCR7 formulations.
- Successful encapsulation of SCR7 within a polymer matrix.
Conclusions:
- Polymer encapsulation is a viable strategy to enhance SCR7 bioavailability.
- The developed formulation retains in vitro anticancer activity.
- This approach may overcome limitations for SCR7's clinical use.
