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Decrease of Urotensin II activity can impact on the volume status in predialysis chronic kidney disease.
Banu Yilmaz1, Akar Yilmaz, Funda Sari
1Clinic of Nephrology, Antalya Training and Research Hospital , Antalya , Turkey .
Renal Failure
|January 23, 2015
Summary
Low levels of Urotensin II (U-II) are linked to overhydration and may indicate a potential therapeutic target for cardio-renal syndrome, independent of other overhydration markers.
Area of Science:
- Cardiology
- Nephrology
- Endocrinology
Background:
- Urotensin II (U-II) is implicated in renal sodium retention.
- The role of U-II in fluid overload states requires further investigation.
Purpose of the Study:
- To investigate the relationship between Urotensin II levels and overhydration.
- To identify U-II as a potential predictor of overhydration and cardio-renal syndrome.
Main Methods:
- 107 patients were categorized into overhydrated and normohydrated groups.
- Assessed hydration status, arterial stiffness, blood pressure, and echocardiographic parameters.
- Measured U-II levels using Human ELISA kits and analyzed correlations with overhydration predictors.
Main Results:
- Overhydrated patients exhibited significantly lower U-II levels.
- U-II was an independent predictor of overhydration, alongside male sex, left ventricular mass index, left atrial volume index, and hemoglobin.
- Low U-II levels correlate with adverse cardiovascular events.
Conclusions:
- Low U-II levels are associated with overhydration and may serve as an independent predictor.
- U-II represents a potential therapeutic target for patients with hypervolemic cardio-renal syndrome.
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