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Related Experiment Videos

The BLV-induced leukemia--lymphosarcoma complex in sheep.

S Djilali1, A L Parodi

  • 1Laboratoire d'Anatomie Pathologique, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.

Veterinary Immunology and Immunopathology
|October 1, 1989
PubMed
Summary

Sheep infected with Bovine Leukemia Virus (BLV) can develop persistent lymphocytosis (PL) and lymphosarcoma, primarily affecting B-cells. BLV utilizes the immune system

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Area of Science:

  • Veterinary Virology
  • Immunology
  • Oncology

Background:

  • Sheep are susceptible to Bovine Leukemia Virus (BLV) infection.
  • BLV infection can lead to hematological disorders and lymphosarcoma in sheep.
  • Understanding BLV pathogenesis is crucial for animal health and retroviral research.

Purpose of the Study:

  • To investigate the hematological and immunological consequences of BLV infection in sheep.
  • To characterize the cellular lineage of BLV-induced lymphoid disorders.
  • To explore the role of immune system activation in BLV replication and transmission.

Main Methods:

  • Monitoring anti-BLV antibody production post-inoculation.
  • Detection of persistent lymphocytosis (PL) and lymphosarcoma.

Related Experiment Videos

  • In vitro studies using immunolabelling, mitogen stimulation, and lymphocyte cultures.

    • Main Results:

    • Anti-BLV antibodies detected 1-3 months post-inoculation.
    • Persistent lymphocytosis (PL) observed in 50% of infected sheep 10-13 months p.i., identified as a B-cell disorder.
    • Lymphosarcoma developed in 40% of infected sheep within 6 years p.i., also of B-lymphocyte lineage.
    • BLV antigen expression is restricted to B-lymphocytes but stimulated by T-cell mitogens.

    Conclusions:

    • BLV-induced leukemia and lymphoma in sheep are B-cell malignancies.
    • BLV appears to exploit the host immune system's activation pathways for replication.
    • The sheep-BLV model offers insights into retroviral pathogenesis, similar to HIV.