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Related Experiment Videos

The canyon hypothesis.

M G Rossmann1

  • 1Department of Biological Sciences, Purdue University, West Lafayette, IN.

Viral Immunology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Human rhinovirus 14 utilizes a deep surface "canyon" to shield its host cell receptor attachment site from the immune system. This conserved structure protects vital residues, preventing immune attack and ensuring viral replication.

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Area of Science:

  • Virology
  • Structural Biology
  • Immunology

Background:

  • Human rhinovirus 14 possesses a unique surface depression, termed a
  • canyon
  • surrounding its vertices.
  • This canyon is inaccessible to antibody binding sites, unlike more exposed viral surface features.

Purpose of the Study:

  • To investigate the role of the human rhinovirus 14
  • canyon
  • in host cell receptor attachment.
  • To explore the implications of this structure for viral immune evasion strategies.

Main Methods:

  • Analysis of the three-dimensional structure of human rhinovirus 14.
  • Examination of site-specific mutations within the canyon.

Related Experiment Videos

  • Observation of conformational changes induced by small organic molecule binding.

    • Main Results:

    • The canyon's structure protects conserved residues essential for receptor recognition from immune surveillance.
    • Experimental data, including mutations and molecular binding studies, confirm the canyon as the receptor attachment site.
    • Similar depressions on influenza virus also mediate host cell interaction.

    Conclusions:

    • The
    • canyon
    • is a critical structure for human rhinovirus 14 receptor binding and immune evasion.
    • This viral immune evasion strategy may be conserved across various viruses, including picornaviruses and human immunodeficiency virus.