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Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

15.0K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
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Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

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Related Experiment Video

Updated: Apr 18, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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Proteogenomics: emergence and promise.

Sam Faulkner1, Matthew D Dun, Hubert Hondermarck

  • 1Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, Life Science Building, University of Newcastle, Callaghan, NSW 2308, Australia.

Cellular and Molecular Life Sciences : CMLS
|January 23, 2015
PubMed
Summary

Proteogenomics integrates gene, RNA, and protein data for a comprehensive view of cell functions. This approach is revolutionizing oncology and holds promise for broader biomedical applications.

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Area of Science:

  • Biochemistry
  • Genomics
  • Proteomics

Background:

  • Proteogenomics integrates multi-omics data for a unified understanding of cellular functions.
  • Simultaneous analysis of gene structure, RNA expression, and protein synthesis is now technically feasible.
  • This offers a novel perspective on complex molecular processes.

Purpose of the Study:

  • To review recent developments in proteogenomics.
  • To discuss current challenges in the field.
  • To explore future perspectives and applications of proteogenomics.

Main Methods:

  • Integration of genomics, transcriptomics, and proteomics data.
  • Analysis of gene structure, RNA expression, and protein synthesis.
  • Examination of post-translational modifications.

Main Results:

  • Proteogenomics provides a global view of molecular processes.
  • Recent studies highlight its value in defining tumor molecular signatures in oncology.
  • The approach is anticipated for translation to other biomedical and life science areas.

Conclusions:

  • Proteogenomics represents a significant advancement in understanding cellular functions.
  • Its application in oncology is demonstrating clear value.
  • Future expansion into diverse biomedical fields is expected.