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[Mecanisms of pharmacokinetic interactions involving oral anticancer agents]

Dominique Levêque1, Céline Duval1, Charlotte Poulat1

  • 1Pharmacie, hôpital Hautepierre, avenue Molière, 67000 Strasbourg, France.

Bulletin Du Cancer
|January 23, 2015
PubMed

Insights

Oral anticancer drugs, especially kinase inhibitors, can interact with various factors affecting absorption and elimination. Understanding these pharmacokinetic drug interactions is crucial for safe and effective cancer treatment.

Area of Science:

  • Pharmacology
  • Oncology
  • Drug Metabolism

Context:

  • Oral anticancer agents, including kinase inhibitors, are widely used in cancer therapy.
  • These drugs are susceptible to pharmacokinetic drug interactions (PDIs).
  • Factors like food, smoking, and other medications can significantly alter drug levels.

Purpose:

  • To review the mechanisms of PDIs involving oral anticancer agents.
  • To highlight common interacting factors and their impact.
  • To inform clinical practice regarding PDI management.

Summary:

  • Oral anticancer drugs and kinase inhibitors undergo interactions affecting absorption and elimination.
  • Interacting factors include food, fruit juices, cigarette smoke, acid-reducing agents, and other drugs (inducers/inhibitors).
  • Some anticancer agents can also act as inducers or inhibitors, leading to further drug interactions.

Impact:

  • Enhanced understanding of PDI mechanisms for oral anticancer agents.
  • Improved patient safety through awareness of interacting factors.
  • Guidance for clinicians to minimize adverse events and optimize therapy.
Keywords:
Agents anticancéreux orauxDrug interactionInteraction médicamenteusesOral anticancer agentsPharmacocinétiquePharmacokinetics

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