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Updated: Apr 18, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
Published on: May 18, 2020
Synaptic consolidation: from synapses to behavioral modeling
Lorric Ziegler1, Friedemann Zenke1, David B Kastner1
1School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland.
Abstract:
Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.
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