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Cutaneous drug reactions in children: a multicentric study
Nursel Dilek1, Hatice Uce Özkol2, Ayse Akbaş3
1Dermatology Department, Recep Tayyip Erdoğan University Medical Faculty Hospital, Rize, Turkey. Head of the Department: Yunus Saral.
Postepy Dermatologii I Alergologii
|January 23, 2015
Summary
Cutaneous adverse drug reactions (CADRs) affect approximately 2.5% of pediatric outpatients. This study analyzed CADR patterns in children, finding urticaria and angioedema most common, often caused by antimicrobials.
Area of Science:
- Pediatric Dermatology
- Pharmacovigilance
- Drug Safety
Background:
- Cutaneous adverse drug reactions (CADRs) are estimated to occur in 2.5% of pediatric outpatients.
- Understanding CADR patterns is crucial for patient safety and effective treatment.
Purpose of the Study:
- To analyze CADR reports in pediatric patients from three university hospitals.
- To describe common, serious, and unique cutaneous drug eruption patterns.
- To identify frequently implicated drugs and reaction types in children.
Main Methods:
- Retrospective review of patient data from three university hospitals.
- Diagnosis based on clinical history, findings, and laboratory tests.
- Classification of CADRs into seven distinct categories, including urticaria, erythema multiforme, and Stevens-Johnson syndrome.
Main Results:
- A total of 122 pediatric patients with CADRs were included.
- The most frequent reactions observed were urticaria and angioedema.
- Antimicrobials were identified as the most common cause of CADRs, with most patients having no prior exposure to the causative agent.
Conclusions:
- Multicentric studies are valuable for understanding rare CADRs in pediatric populations.
- This research provides insights into cutaneous eruption patterns associated with commonly used drugs in children.
- Findings can inform clinical practice and drug safety monitoring in pediatric care.
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