Related Experiment Video
Updated: Apr 18, 2026
10:09
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
8.0K
Characterization of a mammalian prosencephalic functional plan.
Sophie Croizier1, Sandrine Chometton1, Dominique Fellmann1
1EA 3922, SFR FED 4234, UFR Sciences Médicales et Pharmaceutiques, Université de Franche-Comté Besançon, France.
Frontiers in Neuroanatomy
|January 23, 2015
Summary
The hypothalamus develops from a molecularly diverse embryonic neural tube region, forming distinct axonal tracts. These pathways establish a foundational blueprint for prosencephalic brain connectivity.
Area of Science:
- Neuroscience
- Developmental Biology
- Neuroanatomy
Background:
- Hypothalamic organizational concepts have evolved with systematic pathway investigation.
- Understanding the hypothalamus's early development is crucial for comprehending brain connectivity.
Purpose of the Study:
- To review the embryonic development of the hypothalamus.
- To describe the formation of key hypothalamic pathways and their role in brain organization.
Main Methods:
- Review of existing literature on hypothalamic development and neuroanatomy.
- Analysis of molecular heterogeneity and cellular differentiation in the embryonic neural tube.
Main Results:
- The hypothalamus originates from a molecularly heterogeneous region of the embryonic neural tube.
- Early differentiation forms a neuronal cell cord defining longitudinal (tractus postopticus/retinian) and transverse (supraoptic tract/olfactory) axes.
- These tracts guide the formation of major connections between the telencephalon and hypothalamus/ventral midbrain.
Conclusions:
- An early, basic organizational plan exists for the prosencephalic connectome.
- The identified axonal tracts are fundamental to establishing hypothalamic and broader brain circuitry.
Related Concept Videos
01:30Diencephalon: Anatomical Regions
7.1K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
7.1K
01:23Diencephalon: Hypothalamus and Coordination
5.5K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
5.5K
01:15Functional Brain Systems: Limbic System
9.5K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
9.5K
01:30Organization of the Brain
4.0K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
4.0K
01:30Neurulation
47.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.7K
01:26Cerebrum: Anatomical Overview I
7.0K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
7.0K