Related Experiment Video
Updated: Apr 18, 2026

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
Published on: December 22, 2014
Finding and identifying the viral needle in the metagenomic haystack: trends and challenges
Hayssam Soueidan1, Louise-Amélie Schmitt2, Thierry Candresse3
1Bordeaux Bioinformatics Center, Université de Bordeaux Bordeaux, France ; INSERM U1035, Université de Bordeaux Bordeaux, France.
Abstract:
Collectively, viruses have the greatest genetic diversity on Earth, occupy extremely varied niches and are likely able to infect all living organisms. Viral infections are an important issue for human health and cause considerable economic losses when agriculturally important crops or husbandry animals are infected. The advent of metagenomics has provided a precious tool to study viruses by sampling them in natural environments and identifying the genomic composition of a sample. However, reaching a clear recognition and taxonomic assignment of the identified viruses has been hampered by the computational difficulty of these problems. In this perspective paper we examine the trends in current research for the identification of viral sequences in a metagenomic sample, pinpoint the intrinsic computational difficulties for the identification of novel viral sequences within metagenomic samples, and suggest possible avenues to overcome them.
More Related Videos
11:12Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm
Published on: April 12, 2017
13:45Using a Pan-Viral Microarray Assay Virochip to Screen Clinical Samples for Viral Pathogens
Published on: April 27, 2011
Related Concept Videos
Human Virome
Viral Mutations
Microorganisms in Medicine and Therapeutics
Viral Recombination
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....