Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Extracellular Matrix01:26

Extracellular Matrix

6.8K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
6.8K
The Extracellular Matrix01:42

The Extracellular Matrix

91.5K
Overview
91.5K
The Extracellular Matrix01:29

The Extracellular Matrix

13.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.8K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

3.8K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.8K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

10.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
10.0K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

3.8K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reference intervals for lysosomal glucocerebrosidase activity in the healthy population.

Scandinavian journal of clinical and laboratory investigation·2026
Same author

Enhanced ligand-free attachment of osteoblast to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles.

International journal of biological macromolecules·2021
Same author

Surface modified cellulose scaffolds for tissue engineering.

Cellulose (London, England)·2020
Same author

Mechanically robust cationic cellulose nanofibril 3D scaffolds with tuneable biomimetic porosity for cell culture.

Journal of materials chemistry. B·2020
Same author

Modulating cell response on cellulose surfaces; tunable attachment and scaffold mechanics.

Cellulose (London, England)·2020
Same author

Predicting Ligand-Free Cell Attachment on Next-Generation Cellulose-Chitosan Hydrogels.

ACS omega·2018

Related Experiment Video

Updated: Apr 18, 2026

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

17.7K

The extracellular matrix: Structure, composition, age-related differences, tools for analysis and applications for

Jaspreet K Kular1, Shouvik Basu2, Ram I Sharma3

  • 1Department of Chemical Engineering, University of Bath, Bath, UK ; Centre for Regenerative Medicine, University of Bath, Bath, UK.

Journal of Tissue Engineering
|January 23, 2015
PubMed
Summary

The extracellular matrix (ECM) provides structural support and influences cell functions vital for tissue engineering. This review covers ECM composition, function, aging effects, and analytical methods for tissue regeneration research.

Keywords:
Extracellular matrixageingconnective tissuescaffoldstissue engineeringwound healing

More Related Videos

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
07:28

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Published on: July 23, 2015

28.9K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.9K

Related Experiment Videos

Last Updated: Apr 18, 2026

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

17.7K
Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis
07:28

Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis

Published on: July 23, 2015

28.9K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.9K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • The extracellular matrix (ECM) is a complex network of macromolecules providing structural and biochemical support to cells.
  • ECM composition and structure are critical regulators of cellular behaviors like migration, wound healing, and differentiation.
  • Understanding the ECM is crucial for advancing tissue engineering applications, particularly in scaffold design.

Purpose of the Study:

  • To review current knowledge on the composition, structure, and functions of the ECM.
  • To explore the impact of aging on ECM remodeling and its subsequent effects on cellular functions.
  • To summarize analytical technologies used for studying the ECM and related cellular processes.

Main Methods:

  • Literature review of scientific publications on extracellular matrix.
  • Synthesis of current research on ECM composition, structure, and function.
  • Analysis of studies investigating aging effects on ECM and cellular processes.
  • Review of analytical techniques for ECM and cellular analysis.

Main Results:

  • The ECM comprises diverse proteins and sugars that dictate cellular behavior.
  • Aging significantly alters ECM remodeling, impacting cellular functions.
  • Various analytical technologies are available for studying ECM and its role in cellular processes.

Conclusions:

  • A comprehensive understanding of the ECM, including aging effects, is essential for developing effective tissue engineering strategies.
  • The ECM serves as a critical component for designing advanced biomaterial scaffolds.
  • Further research utilizing advanced analytical tools will enhance ECM-based tissue regeneration therapies.