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An in vivo Assay to Test Blood Vessel Permeability
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Mechanisms regulating endothelial permeability.

Sukriti Sukriti1, Mohammad Tauseef1, Pascal Yazbeck1

  • 1Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois, USA.

Pulmonary Circulation
|January 23, 2015
PubMed
Summary
This summary is machine-generated.

This review explores how intercellular junctions in endothelial cells maintain barrier function and how inflammatory agonists disrupt them, leading to edema. It focuses on new insights into adherens junction alterations during inflammation.

Keywords:
adherens junctionspermeabilitysignaling mechanismsvascular endothelium

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Area of Science:

  • Endothelial biology
  • Vascular physiology
  • Inflammation research

Background:

  • The endothelial monolayer separates tissue from blood, regulating fluid balance and defense via intercellular junctions.
  • Edemagenic agonists compromise endothelial barrier function, causing inflammatory edema and potentially fatal conditions like acute respiratory distress syndrome.

Purpose of the Study:

  • To review the mechanisms maintaining endothelial intercellular junctions under normal and inflammatory conditions.
  • To highlight novel concepts regarding adherens junction alterations following inflammatory stimuli.

Main Methods:

  • Literature review of endothelial barrier function.
  • Analysis of intercellular junction dynamics.
  • Focus on adherens junction regulation in inflammation.

Main Results:

  • Intercellular junctions dynamically regulate endothelial barrier integrity.
  • Edemagenic agonists induce junction opening, leading to edema formation.
  • Adherens junctions undergo significant alterations upon inflammatory stimulation.

Conclusions:

  • Understanding intercellular junction regulation is crucial for managing inflammatory diseases.
  • New concepts on adherens junction dynamics offer therapeutic targets for edema control.