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Reaction of trans-2-chlorovinylarsine oxide with polydeoxynucleotides

K Dill¹, E R Adams, S D Davis

¹Department of Chemistry, Clemson University, SC 29634-1905.

Drug and Chemical Toxicology

|September 1, 1989

Abstract:

Trans-2-chlorovinylarsine oxide (in DCl/acetone-d6) was added to various polydeoxynucleotides. The arsenical did react with poly[dG].poly[dC], releasing guanine, and resulting in a partial apurinic duplex.

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