Related Experiment Video

Updated: Apr 18, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

3.5K

Precore/Core promoter variants to predict significant fibrosis in both HBeAg positive and negative chronic hepatitis

Martine Lapalus1, Cédric Laouenan2,3, Ana-Carolina Cardoso1

  • 1Team Physiopathology and Treatment of Viral Hepatitis, Centre de Recherche sur l'Inflammation, Laboratory of Excellence Labex INFLAMEX, INSERM, UMR-1149, University Denis Diderot Paris 7, PRES Sorbonne Paris Cité, Paris, France.

Liver International : Official Journal of the International Association for the Study of the Liver
|January 23, 2015
PubMed

Insights

Significant fibrosis in chronic hepatitis B (CHB) patients is predicted by age, ALT, HBV-DNA levels, and HBV variants. These factors help identify patients with severe liver disease, aiding in non-invasive fibrosis assessment.

Area of Science:

  • Hepatology
  • Virology
  • Gastroenterology

Background:

  • Assessing liver fibrosis is crucial for managing chronic hepatitis B (CHB).
  • Non-invasive markers are needed to identify significant fibrosis in treatment-naïve CHB patients.
  • This study investigates host and viral factors associated with liver fibrosis staging.

Purpose of the Study:

  • To identify non-invasive markers for significant fibrosis (METAVIR F ≥ 2) in CHB.
  • To explore the relationship between fibrosis and host/viral factors.
  • To evaluate the predictive accuracy of identified markers.

Main Methods:

  • Included 377 treatment-naïve CHB patients with liver biopsy.
  • Assessed fibrosis using the METAVIR score.
  • Determined host factors (age, gender, ALT) and viral factors (HBsAg, HBV-DNA, genotype, BCP/PC variants).

Main Results:

  • 39% of patients had significant fibrosis (F ≥ 2).
  • Age, male gender, higher ALT and HBV-DNA levels, and BCP/PC variants were associated with fibrosis.
  • Multivariate analysis identified age, HBV variants, HBV-DNA, and ALT as independent predictors of significant fibrosis (c-index 0.76).

Conclusions:

  • Age, ALT, HBV-DNA, and HBV variants are independent predictors of significant fibrosis in CHB.
  • Patients with BCP variants face a higher risk of severe liver disease.
  • These factors can aid in the non-invasive prediction of significant fibrosis.
Abstract

Keywords:
basal core promoter variantchronic hepatitis Bnon-invasive markerprecore variantsignificant fibrosis

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.1K
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

12.4K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
63
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
3
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
1
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
19.8K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

4.4K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.4K