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Updated: Apr 18, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
Published on: June 29, 2021
[Haemophilus influenzae type b meningitis in a vaccinated, immunocompetent infant with reactive arthritis]
Kristin Brønnum Nystrup1, Line Kønig Wilms
1Pædiatrisk Afdeling, Næstved Sygehus, Ringstedgade 61, 4700 Næstved. kristinnystrup@gmail.com.
Abstract:
Due to the excellent immunogenicity of the Haemophilus influenzae type b (Hib) conjugate vaccines, vaccine failures are rarely seen in patients following the recommended national immunization programmes. We present an infant with Hib meningitis despite relevant prophylaxis, without known risk factors such as medical co-morbidity, immunosuppression, immunoglobulin deficiency or prematurity. Later, a reactive arthritis developed. In conclusion, Hib-meningitis can occur in vaccinated, immunocompetent patients, and antibiotics covering Hib should be chosen in patients presenting with meningitis.
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