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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Cytomegalovirus Disease01:27

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Autoimmune Disorders01:29

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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[Common variable immunodeficiency can present as a multisystemic disorder].

Rasmus Møller Jørgensen, Annebirthe Bo Hansen, Stephen V Cannon

  • 1Hospitalsenhed Vest, Medicinsk Afdeling, Lægårdvej 12, 7500 Holstebro. npeterslund@gmail.com.

Ugeskrift for Laeger
|January 24, 2015
PubMed
Summary
This summary is machine-generated.

Common variable immunodeficiency (CVID) is a frequent primary immunodeficiency. Early diagnosis and understanding its complex presentations, like the sarcoidosis-like variant and immunoglobulin subclass impact, are crucial for effective management.

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Area of Science:

  • Immunology
  • Clinical Medicine

Background:

  • Common variable immunodeficiency (CVID) is the second most prevalent primary immunodeficiency, affecting approximately 1 in 10,000 to 50,000 individuals.
  • The clinical management of CVID presents challenges in achieving early diagnosis and implementing efficient supportive care strategies.

Observation:

  • CVID diagnosis is often delayed, leading to a prolonged pre-diagnostic period.
  • A specific focus is placed on the sarcoidosis-like variant of CVID.
  • The potential influence of immunoglobulin subclass deficiency on CVID presentation and progression is explored.

Findings:

  • The article highlights the inherent complexity of CVID, emphasizing diagnostic delays.
  • It specifically addresses the sarcoidosis-like phenotype associated with CVID.
  • The role of immunoglobulin subclass deficiencies in CVID pathogenesis and clinical manifestation is investigated.

Implications:

  • Improved diagnostic strategies are needed to shorten the pre-diagnostic period for CVID patients.
  • Recognizing the sarcoidosis-like variant can aid in differential diagnosis and patient management.
  • Understanding immunoglobulin subclass deficiencies may lead to more personalized and effective CVID therapies.