Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

1
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
1
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

1
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
1
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

2
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
2

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergency radiology of severe acute injury in extreme alpine summer sports: a pictorial essay.

Emergency radiology·2026
Same author

SafeTy and effectiveness of Atogepant accoRding to the IHS outcome categories: A multicentric, prospective observational study in real life (the 24-week STAR study).

Cephalalgia : an international journal of headache·2026
Same author

Prevalence of Lewy body pathology and phenotypic associations in patients with mild cognitive impairment: Evidence from the Interceptor study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Efficacy and safety of eptinezumab in adults with chronic migraine and medication-overuse headache who also received patient education: 24-week results of the randomized RESOLUTION trial.

The journal of headache and pain·2026
Same author

Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine - data from the REFINE study.

Cephalalgia : an international journal of headache·2026
Same author

Quadrato Motor Training in Parkinson's Disease: Resting-State fMRI Changes and Exploratory Whole-Brain Radiomics.

Bioengineering (Basel, Switzerland)·2026

Related Experiment Video

Updated: Apr 18, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.6K

Cortical brain connectivity evaluated by graph theory in dementia: a correlation study between functional and

Fabrizio Vecchio1, Francesca Miraglia1, Giuseppe Curcio2

  • 1Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.

Journal of Alzheimer'S Disease : JAD
|January 24, 2015
PubMed
Summary

Alzheimer's disease and mild cognitive impairment are linked to reduced fractional anisotropy (FA) in the corpus callosum. This structural damage correlates with impaired brain connectivity, particularly between hemispheres.

Keywords:
Alzheimer's diseaseEEGdelta and alpha bandsdiffusion tensor imagingfunctional connectivitygraph theorymild cognitive impairmentsLORETA/eLORETA

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K
Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
08:51

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

6.2K

Related Experiment Videos

Last Updated: Apr 18, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.6K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K
Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
08:51

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

6.2K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Brain Connectivity

Background:

  • Functional connectivity analyzes synchronized activity in distinct brain regions.
  • Diffusion Tensor Imaging (DTI) detects structural brain connections via fractional anisotropy (FA).
  • Reduced FA in the corpus callosum is observed in Alzheimer's disease (AD) and mild cognitive impairment (MCI).

Purpose of the Study:

  • To investigate correlations between structural damage (DTI) and functional brain integration abnormalities (EEG).
  • To assess how corpus callosum integrity relates to interhemispheric functional connectivity.

Main Methods:

  • 40 participants (9 controls, 10 MCI, 10 mild AD, 11 moderate AD) underwent MRI-DTI and resting-state EEG.
  • Brain networks were constructed using eLORETA lagged linear connectivity.
  • Graph theory measures, including characteristic path length, were analyzed.

Main Results:

  • Reduced callosal FA was associated with decreased interhemispheric functional connectivity.
  • Increased delta and decreased alpha path lengths indicated functional disconnection.
  • Global functional measures reflected structural fiber loss and could predict it.

Conclusions:

  • Corpus callosum damage, detected by DTI, impacts global brain functional connectivity.
  • Functional connectivity measures can serve as early indicators of structural changes in neurodegenerative diseases like AD.