Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Electrocardiogram01:29

Electrocardiogram

10.1K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
10.1K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

4.1K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
4.1K
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

803
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
803
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

483
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
483
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

805
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
805

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Objectively Measured Cardiorespiratory Fitness as a Potential Biomarker for Alzheimer's Disease Risk in Older Adults: Evidence from the Generation 100 Study.

Medicine and science in sports and exercise·2026
Same author

Toward Precision Cardiac Rehabilitation: Current Limitations and Future Opportunities of Omics and Artificial Intelligence.

Sports medicine (Auckland, N.Z.)·2026
Same author

Acute Finnish sauna heat exposure induces stronger immune cell than cytokine responses.

Temperature (Austin, Tex.)·2026
Same author

GLP-1 Receptor Agonists and the Kidney: Progress With Important Caveats.

Mayo Clinic proceedings·2026
Same author

Associations of Physical Activity and Sedentary Time From Childhood to Adolescence With Cognition in Adolescence: The PANIC Study.

Pediatric exercise science·2026
Same author

Combined Impact of Cardiorespiratory Fitness and Exercise Systolic Blood Pressure on Cardiovascular and All-Cause Mortality: A Long-Term Follow-Up Study.

The American journal of cardiology·2026

Related Experiment Video

Updated: Apr 18, 2026

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
09:23

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography

Published on: November 24, 2016

14.0K

T-wave inversion and mortality risk.

Sudhir Kurl1, Timo H Mäkikallio, Jari A Laukkanen

  • 1Institute of Public Health and Clinical Nutrition, Department of Medicine, University of Eastern Finland , Kuopio , Finland.

Annals of Medicine
|January 24, 2015
PubMed
Summary

T-wave inversion (TWI) on an electrocardiogram (ECG) strongly predicts mortality from coronary heart disease (CHD), cardiovascular disease (CVD), and all causes in the general population. This risk is amplified in men with hypertension, high LDL cholesterol, and obesity.

Keywords:
MenT-wave inversionmortalityrisk

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.9K
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

12.1K

Related Experiment Videos

Last Updated: Apr 18, 2026

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
09:23

Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography

Published on: November 24, 2016

14.0K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.9K
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

12.1K

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Epidemiology

Background:

  • Electrocardiogram (ECG) findings are crucial for cardiovascular risk assessment.
  • T-wave inversion (TWI) is a notable ECG abnormality.
  • Its prognostic significance in the general population requires further elucidation.

Purpose of the Study:

  • To determine the predictive value of T-wave inversion (TWI) on routine ECG for mortality.
  • To assess TWI's prognostic impact across different risk groups within the general population.

Main Methods:

  • Prospective, population-based follow-up study.
  • Inclusion of 1814 men aged 42-60 years without baseline coronary heart disease (CHD).
  • Analysis of ECGs and mortality data over an average follow-up of 21 years.

Main Results:

  • T-wave inversion (TWI) was associated with significantly increased mortality.
  • Relative risks (RR) for CHD, cardiovascular disease (CVD), and all-cause mortality were elevated even after adjusting for conventional risk factors.
  • Adjusted RRs for CHD, CVD, and all-cause mortality were 2.62, 2.18, and 1.41, respectively.

Conclusions:

  • T-wave inversion (TWI) is a robust independent predictor of CHD, CVD, and all-cause mortality in the general male population.
  • The mortality risk associated with TWI is further heightened in individuals with hypertension, high LDL cholesterol, and obesity.