Evaluation of new antiviral agents: II. The use of animal models

Antiviral chemotherapy has become a reality in the 1980s. Since the use of animal models in the testing of new antiviral agents is an inevitable step prior to clinical trial in human patients, it is important to understand the basic principles of using model systems. Briefly reviewed in this paper are the heterologous and homologous animal models which have been used for studies of various herpesvirus infections in humans. Discussions of the use of the guinea pig models mainly, for members of the Herpesviridae are presented in more detail. Precautions needed for the development of new animal models, and suggestions proposed for the use of animal models for testing new antiviral agents are outlined. It is hoped that new animal models will be developed in the foreseeable future for evaluating the much needed effective but less toxic antiviral agents for a variety of human viral diseases.