Related Experiment Video
Updated: Apr 18, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Lipopolysaccharide-induced chorioamnionitis causes acute inflammatory changes in the ovine central nervous system
Eveline Strackx, Michelle A R Sparnaaij, Evi Vlassaks
1Department of Pediatrics, Maastricht University Medical Center, P. Debyelaan 25, P.O. Box 5800, 6202AZ Maastricht, The Netherlands. danilo.gavilanes@mumc.nl.
Objective:
To better understand the inflammatory response in the central nervous system (CNS) after lipopolysaccharide (LPS)-induced chorioamnionitis.
Study Design:
Fetal sheep were exposed to intra-amniotic LPS 2 or 14 days before preterm delivery at 125 days of gestation. mRNA levels of cytokines, TLRs and anti-oxidants were determined in different CNS regions.
Results:
Interleukin 1β levels increased in hippocampus, cortex and cerebellum 2 days after LPS exposure, while Interleukin 8 levels increased in the periventricular white matter as well. Levels returned back to control levels after 14 days. Tumor necrosis factor-α levels increased in hippocampus and cortex after 2 days. Toll like receptor 4 levels was upregulated in all grey matter regions 2 and 14 days after exposure. Glutathione s-transferase mRNA levels were lower after 2 and 14 days in all grey matter regions.
Conclusion:
Intra-amniotic LPS exposure causes acute and region-specific changes in inflammatory markers in the fetal brain, with grey matter being more affected than white matter.
Condensation:
Intra-amniotic LPS exposure causes acute and region-specific changes in cytokines, TLR and anti-oxidants levels, with grey matter being more affected than white matter.
More Related Videos
Related Concept Videos
Encephalitis ll: Pathophysiology
Bacterial Meningitis II: Pathophysiology
Acute Pancreatitis II: Pathophysiology
Bacterial Meningitis I: Introduction
Acute Inflammation II: Local and Systemic Effects

