Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphopenia in primary degenerative dementia.

G D Tollefson1, M Godes, J B Warren

  • 1Department of Psychiatry, Ramsey Clinic, St. Paul, Minnesota 55101.

Journal of Psychiatric Research
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of continuous UV-C disinfection on microbial contamination of a handwash basin.

The Journal of hospital infection·2025
Same author

Response to Dr Dancer.

The Journal of hospital infection·2024
Same author

Borderline oxacillin-resistant Staphylococcus aureus: an emerging threat in the hospital environment.

The Journal of hospital infection·2024
Same author

Parent experiences of a remote patient monitoring program enabling early discharge from the neonatal intensive care unit with nasogastric tube feeding.

Journal of neonatal-perinatal medicine·2023
Same author

Final rinse water quality for flexible endoscopy to minimize the risk of post-endoscopic infection. Report from Healthcare Infection Society Working Party.

The Journal of hospital infection·2022
Same author

Automated room decontamination: report of a Healthcare Infection Society Working Party.

The Journal of hospital infection·2022

Patients with primary degenerative dementia show significantly reduced lymphocyte counts, correlating with dementia severity. This finding supports an immune hypothesis for dementia and its associated infection risks.

Area of Science:

  • Neuroimmunology
  • Geriatric Medicine
  • Neurology

Background:

  • The central nervous and immune systems share common properties, including neurotransmitter receptors.
  • Understanding immune system changes in dementia is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate lymphocyte counts in patients with primary degenerative dementia.
  • To explore the relationship between lymphocyte counts and dementia severity.

Main Methods:

  • Compared total lymphocyte counts in 25 dementia patients with age-matched healthy/hypertensive controls.
  • Assessed correlation between lymphocyte counts and dementia severity.
  • Evaluated potential explanatory factors like age, onset, duration, nutritional status, ACTH, and cortisol.

Related Experiment Videos

Main Results:

  • Significantly reduced total lymphocyte counts were observed in dementia patients compared to controls.
  • Lymphocyte reduction correlated with dementia severity.
  • No correlation found with age, onset, or duration; leukocyte counts, nutritional status, ACTH, or cortisol explained the lymphopenia.

Conclusions:

  • The observed lymphopenia in dementia patients supports an immune hypothesis for primary degenerative dementia, such as Alzheimer's type.
  • This finding may have implications for understanding the high risk of infection in dementia patients.