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Published on: May 10, 2021
Calcifications in benfluorex-induced valve heart disease: a misknown association
François Plurien1, Patrick Bruneval, Yannick Jobic
1Cardiology Department, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
Abstract:
Benfluorex, an anorexigenic agent, is recognized to induce noncalcified restrictive valvular regurgitation. We report a well-documented case of a 73-year-old patient who developed heart failure with aortic and mitral regurgitation following benfluorex intake. Echocardiography and peroperative analysis found large mitral annular calcifications and aortic subvalvular calcifications. Pathology confirmed drug-induced valve heart disease (DIVHD). The presence of valvular apparatus calcification should not lead to diagnosis of degenerative valvular disease and a priori preclude the diagnosis of DIVHD.
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