Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

335
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
335
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

366
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
366
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.0K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.0K
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

1.2K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.2K
Blood Supply to the Digestive System01:16

Blood Supply to the Digestive System

4.9K
Splanchnic circulation refers to the network of blood vessels that supply and drain blood from the abdominal organs involved in digestion, including the stomach, liver, pancreas, intestines, and spleen. This circulation delivers essential nutrients and oxygen while removing waste products from these organs.
Blood Supply to the Digestive System: The splanchnic circulation involves three main arteries: the celiac artery (also known as the celiac trunk) and the superior and inferior mesenteric...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MOSAIC: Methylation-Oriented Site Analysis and Information Classifier for Robust Epigenomic Classification of Acute Leukemia in Clinical Cohorts with Variable Tumor Purity.

medRxiv : the preprint server for health sciences·2026
Same author

Post pelvic binder radiograph can identify bladder injury associated with pelvic trauma: A multi-centre observational study.

Injury·2026
Same author

Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomarkers With Severe Dengue.

Journal of medical virology·2026
Same author

The integrated 31-gene expression profile test identifies low-risk patients with cutaneous melanoma who can forego the SLNB procedure: results from a prospective, multicenter trial.

Future oncology (London, England)·2026
Same author

Abdominal cocoon: A rare presentation of abdominal distension in a young adult male-A case report.

JPMA. The Journal of the Pakistan Medical Association·2026
Same author

The Long View, a Long way to go: Palliative Care Along the Transplant Journey.

Transplantation·2026

Related Experiment Videos

Gastrointestinal bleeding with continuous-flow left ventricular assist devices.

Syed Amer1, Parth Shah, Syed Hassan

  • 1Mayo Clinic, Phoenix, AZ, 85054, USA, docusa85@gmail.com.

Clinical Journal of Gastroenterology
|January 24, 2015
PubMed
Summary
This summary is machine-generated.

Patients with continuous-flow left ventricular assist devices (CF-LVADs) face a high risk of gastrointestinal bleeding (GIB). This review details the unique pathophysiology, management, and prevention of GIB in CF-LVAD patients.

Related Experiment Videos

Area of Science:

  • Cardiology
  • Gastroenterology
  • Medical Devices

Background:

  • Continuous-flow left ventricular assist devices (CF-LVADs) are vital for advanced heart failure.
  • Patients with CF-LVADs exhibit a significantly increased risk of gastrointestinal bleeding (GIB).
  • GIB lesions are observed throughout the GI tract, with a higher prevalence in the upper regions.

Purpose of the Study:

  • To comprehensively review the pathophysiology of GIB in CF-LVAD patients.
  • To outline current management strategies for GIB in this population.
  • To discuss complications and preventive measures for GIB in CF-LVAD recipients.

Main Methods:

  • Literature review focusing on GIB in CF-LVAD patients.
  • Analysis of the unique pathophysiological mechanisms contributing to GIB.
  • Synthesis of management and prevention strategies based on existing evidence.

Main Results:

  • GIB pathophysiology in CF-LVAD patients involves coagulopathy, acquired von Willebrand disease, and non-pulsatile flow.
  • Management approaches are tailored to bleeding site and clinical presentation.
  • Preventive strategies include optimizing pump speed, hemodynamic monitoring, and early endoscopy.

Conclusions:

  • Understanding the multifactorial pathophysiology of GIB is crucial for effective management.
  • Proactive prevention strategies are essential to reduce GIB incidence and severity in CF-LVAD patients.
  • Further research may refine therapeutic and preventive interventions for GIB in this high-risk group.