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Plasma pro-surfactant protein B and lung function decline in smokers
Janice M Leung1, John Mayo2, Wan Tan1
1Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
The European Respiratory Journal
|January 24, 2015
Summary
Plasma pro-surfactant protein B (pro-SFTPB) levels predict chronic obstructive pulmonary disease (COPD) severity and lung function decline. Higher pro-SFTPB indicates more severe COPD and faster disease progression in smokers.
Area of Science:
- Pulmonary Medicine
- Biomarker Research
- Respiratory Health
Background:
- Plasma pro-surfactant protein B (pro-SFTPB) is a known lung cancer predictor in smokers.
- Its role in predicting chronic obstructive pulmonary disease (COPD) severity and progression remains unestablished.
Purpose of the Study:
- To evaluate pro-SFTPB as a biomarker for lung function decline in current and former smokers.
- To assess the relationship between plasma pro-SFTPB levels and COPD severity measures.
Main Methods:
- Plasma pro-SFTPB levels were measured in 2503 participants from the Pan-Canadian Early Detection of Lung Cancer Study.
- Linear regression analyzed associations between pro-SFTPB levels and changes in forced expiratory volume in 1 second (FEV1) over 2 years.
- Relationships with baseline FEV1, FEV1/forced vital capacity (FVC), and emphysema burden on CT scans were examined.
Main Results:
- Plasma pro-SFTPB levels showed an inverse relationship with FEV1 % predicted and FEV1/FVC ratio.
- Higher pro-SFTPB levels correlated positively with emphysema burden on CT scans.
- Elevated pro-SFTPB levels were linked to a faster decline in FEV1 over 1 and 2 years.
Conclusions:
- Higher plasma pro-SFTPB levels are associated with increased airflow limitation severity in COPD patients.
- Pro-SFTPB demonstrates potential as a predictive biomarker for COPD progression and lung function decline.
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