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Reverse-dipper pattern of blood pressure may predict lacunar infarction in patients with essential hypertension

B Yan1, L Peng, Q Dong

  • 1Department of Emergency Medicine, the Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

European Journal of Neurology
|January 24, 2015
PubMed

Insights

Hypertension patients with a reverse-dipper blood pressure pattern face a higher risk of lacunar infarction. This finding suggests personalized blood pressure management is crucial for those with elevated nocturnal BP.

Area of Science:

  • Cardiology
  • Neurology
  • Hypertension Research

Background:

  • Circadian blood pressure (BP) fluctuations vary significantly in essential hypertension patients.
  • BP patterns may hold prognostic value for stroke risk.
  • The impact of the reverse-dipper BP pattern on lacunar infarction incidence in hypertensive individuals is unclear.

Purpose of the Study:

  • To investigate the association between reverse-dipper BP pattern and the incidence of lacunar infarction in hypertensive patients.
  • To identify clinical risk factors, including BP patterns, related to lacunar infarction.

Main Methods:

  • 362 hypertensive patients were enrolled.
  • 24-hour ambulatory BP monitoring (ABPM) was used to assess BP patterns.
  • Multinomial logistic regression analyzed relationships between lacunar infarction and clinical factors.

Main Results:

  • 93 patients (25.7%) exhibited a reverse-dipper BP pattern.
  • Lacunar infarction rates were highest in the reverse-dipper group compared to other BP patterns.
  • Reverse-dipper BP pattern (OR 2.492) and age (OR 1.084) were independently associated with lacunar infarction.

Conclusions:

  • The reverse-dipper BP pattern may be an independent risk factor for lacunar infarction.
  • Elevated nocturnal blood pressure warrants attention in hypertensive patients.
  • Personalized BP management strategies are recommended for patients with reverse-dipper patterns.
Abstract

Keywords:
blood pressureessential hypertensionlacunar infarctionreverse-dipper pattern

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