Related Experiment Video
Updated: Apr 18, 2026

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
[Papillary edema in Muckle-Wells syndrome].
G Wirths1, U Grenzebach2, N Eter2
1Universitätsaugenklinik Münster, Domagkstr. 15, 48149, Münster, Deutschland. Gabriele.wirths@ukmuenster.de.
Papillary edema can be an isolated symptom or linked to conditions like Muckle-Wells syndrome. This rare autoinflammatory disorder causes optic disc swelling and increased intracranial pressure due to interleukin-1β overproduction.
Area of Science:
- Neurology
- Immunology
- Genetics
Background:
- Papillary edema, or optic disc swelling, can manifest independently or as a secondary symptom.
- It is associated with increased intracranial pressure, various syndromes, and certain medications.
Observation:
- Muckle-Wells syndrome, a rare autoinflammatory disease, presents with optic disc swelling and recurrent intracranial pressure spikes.
- This condition is part of the cryopyrin-associated periodic syndromes (CAPS) spectrum, alongside FCAS and NOMID.
Findings:
- CAPS disorders often stem from genetic mutations causing interleukin-1β (IL-1β) overproduction.
- This inflammatory cascade results in characteristic symptoms like skin rash, fever, fatigue, joint pain, and conjunctivitis.
Implications:
- Understanding the link between Muckle-Wells syndrome and papillary edema is crucial for diagnosis.
- Targeting IL-1β may offer therapeutic strategies for CAPS and associated symptoms.
- Early diagnosis and management of CAPS can prevent severe neurological complications.
More Related Videos
07:59Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
Published on: July 28, 2018
08:13In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
Published on: November 11, 2025
Related Concept Videos
Cytotoxic Edema: Pathophysiology
Nephrotic Syndrome I : Introduction
Cerebral Edema l: Introduction
Pulmonary Edema II: Pathophysiology
Cerebral Edema ll: Pathophysiology
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...