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Spontaneous and nerve-evoked quantal transmission in regenerated motor terminals
F Di Gregorio1, R Fesce, S Cereser
1Department of Peripheral Nervous System Research, Fidia Research Laboratories, Abano Terme, Italy.
Cell Biology International Reports
|December 1, 1989
Abstract:
Quantal acetylcholine release was studied in sciatic nerve-extensor digitorum longus muscle preparations from normal rats and in reinnervated muscles at different times following peroneus nerve crush. The efficiency of nerve-evoked transmission was regained almost completely at a time (20 days after crush) when the secretory response to increased extracellular K+ was very weak. This suggests that K+-induced secretion might be activated through mechanisms at least partially different from those involved in the response to nerve stimulation.