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Updated: Apr 18, 2026

Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons
Published on: November 6, 2017
Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy
Marisela Méndez-Armenta1, Concepción Nava-Ruíz1, Daniel Juárez-Rebollar1
1Laboratorio de Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Insurgentes Sur 3877, La Fama, CP 14269, Tlalpan, DF, Mexico.
Abstract:
Epilepsy is considered one of the most common neurological disorders worldwide. Oxidative stress produced by free radicals may play a role in the initiation and progression of epilepsy; the changes in the mitochondrial and the oxidative stress state can lead mechanism associated with neuronal death pathway. Bioenergetics state failure and impaired mitochondrial function include excessive free radical production with impaired synthesis of antioxidants. This review summarizes evidence that suggest what is the role of oxidative stress on induction of apoptosis in experimental models of epilepsy.

