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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

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Published on: November 5, 2019

Group A Streptococcal meningitis in adults.

Marjolein J Lucas¹, Matthijs C Brouwer¹, Sandra Bovenkerk²

¹Academic Medical Center, Center of Infection and Immunity Amsterdam (CINIMA), Department of Neurology, PO Box 22660, 1100DD Amsterdam, The Netherlands.

The Journal of Infection

|January 24, 2015

Summary

Group A Streptococcus (GAS) meningitis is rare but severe, often leading to complications like subdural empyema. Specific GAS genotypes (emm1 and cc28) are linked to empyema development.

Keywords:

Complications Empyema Group A streptococcus Meningitis incidence

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Last Updated: Apr 18, 2026

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A Murine Model of Group B Streptococcus Vaginal Colonization

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Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

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Published on: September 25, 2014

Area of Science:

Infectious Diseases
Neurology
Microbiology

Background:

Group A Streptococcus (GAS) is a common pathogen, but GAS meningitis is a rare complication.
Understanding the epidemiology and clinical spectrum of GAS meningitis is crucial for patient outcomes.

Purpose of the Study:

To determine the incidence, clinical characteristics, and bacterial genotype of group A streptococcal (GAS) meningitis in the Netherlands.
To identify risk factors and outcomes associated with GAS meningitis.

Main Methods:

Nationwide cohort study of adult community-acquired bacterial meningitis cases in the Netherlands (2006-2013).
Assessed incidence, clinical presentation, complications, treatment, and outcomes.
Bacterial genotyping of GAS isolates was performed.

Main Results:

GAS meningitis accounted for 2% (26/1322) of community-acquired bacterial meningitis cases.
Otitis or sinusitis preceded most cases (92%). Complications were frequent (73%), including subdural empyema (35%).
Mortality was 19%, and 52% of survivors had neurologic sequelae. emm1 and cc28 genotypes were associated with subdural empyema (P=0.037).

Conclusions:

Group A Streptococcus (GAS) meningitis is an uncommon yet severe condition.
Subdural empyema is a significant complication, particularly associated with emm1 and cc28 GAS genotypes.