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Updated: Apr 18, 2026
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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Continuous renal replacement therapy in children with multiple organ dysfunction syndrome: a case series
Yan-lin Zhang1, Wei-ping Hu1, Ling-hui Zhou1
1Department of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, People's Republic of China and Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen 361003, People's Republic of China.
Summary
Continuous renal replacement therapy (CRRT) effectively treats critically ill children with multiple organ failure. This study shows CRRT improves organ function and leads to recovery in pediatric patients.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Renal Replacement Therapy
Background:
- Limited data exists on continuous renal replacement therapy (CRRT) for critically ill children.
- Multiple organ failure in children necessitates advanced treatment modalities.
Observation:
- Six pediatric patients (3 days to 8 years) with multiple organ failure received bedside CRRT.
- M60 filter membranes and a modified Port carbonate formula were utilized.
- Treatment protocols included maintaining clotting time and activated partial thromboplastin time.
Findings:
- Five of six patients showed marked improvements, including normalized blood urea nitrogen and creatinine.
- Electrolyte levels stabilized, and other organ function markers improved.
- One patient received CRRT for 241 hours; all five discharged with uneventful recovery.
Implications:
- CRRT demonstrates efficacy in managing critically ill children with multiple organ failure.
- This study supports the use of CRRT as a viable treatment option in pediatric critical care.
- Further research can refine CRRT protocols for improved pediatric patient outcomes.
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