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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Related Experiment Video

Updated: Apr 18, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Two-time-point FDG PET/CT: liver SULmean repeatability.

Abdel K Tahari1, Vasavi Paidpally, Alin Chirindel

  • 11 Russel H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, 601 N Caroline St /JHOC 3235, Baltimore MD 21287.

AJR. American Journal of Roentgenology
|January 24, 2015
PubMed
Summary
This summary is machine-generated.

Repeatability of liver standardized uptake value normalized to lean body mass (SULmean) in (18)F-FDG PET/CT scans shows only fair consistency. Intrapatient variations in liver SULmean ranged from -0.5 to 0.60, indicating limited reliability for serial measurements.

Keywords:
PET/CTliver mean standardized uptake value (SUV) normalized to lean body mass (SULmean)repeatabilitytherapy assessment

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Medical Imaging

Background:

  • Standardized uptake value normalized to lean body mass (SULmean) is a quantitative measure in (18)F-FDG PET/CT.
  • Assessing the repeatability of liver SULmean is crucial for accurate patient monitoring and treatment response evaluation.

Purpose of the Study:

  • To evaluate the repeatability of liver SULmean measurements in the same patients at different time points using (18)F-FDG PET/CT.
  • To determine the intrapatient variability of liver SULmean in a clinical setting.

Main Methods:

  • 130 patients with normal livers underwent two (18)F-FDG PET/CT scans.
  • Liver SULmean was measured in the right lobe using a spherical volume of interest by two readers.
  • Statistical analyses included ANOVA, intraclass correlation coefficient (ICC), and Bland-Altman analysis.

Main Results:

  • Intraclass correlation coefficients (ICC) for repeatability ranged from 0.472 to 0.545.
  • Mean percentage variations in liver SULmean between scans were between 3.55% and 4.65%.
  • The 95% confidence interval for intrapatient variation in liver SULmean was -0.5 to 0.60.

Conclusions:

  • Liver SULmean exhibits only fair repeatability when measured at different time points in the same patient.
  • Significant intrapatient variability exists in absolute liver SULmean measurements, potentially impacting clinical interpretation.
  • The findings suggest caution when relying on serial liver SULmean values for quantitative assessments in clinical practice.