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Advanced targeted nanomedicine.

Mohan C Pereira, Mohan C M Arachchige1, Yana K Reshetnyak1

  • 1Department of Physics, University of Rhode Island, 2 Lippit Rd., Kingston, RI 028881, USA.

Journal of Biotechnology
|January 24, 2015
PubMed
Summary

pH Low Insertion Peptides (pHLIPs) enhance nanoparticle targeting of acidic diseased tissues, improving drug delivery and nanotheranostics for conditions like cancer.

Keywords:
Active targetingEnvironmental targetingNanomedicinePassive targetingTissue aciditypHLIP

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Area of Science:

  • Nanomedicine
  • Drug Delivery
  • Biotechnology

Background:

  • Targeted drug delivery is crucial for effective therapeutics and diagnostics.
  • Nanomedicine offers novel nano-scale systems but requires targeting capabilities.
  • Hypoxia and acidosis are common in many diseases, presenting a therapeutic challenge.

Purpose of the Study:

  • To explore universal methods for targeting diseased tissues using nanomedicine.
  • To investigate the potential of pH Low Insertion Peptides (pHLIPs) for enhanced nanoparticle targeting.
  • To highlight the development of nanotheranostics for diseases like cancer.

Main Methods:

  • Review of various targeting approaches for nano-scale therapeutic and diagnostic materials.
  • Focus on pH-sensitive targeting strategies using pHLIPs.
  • Evaluation of pHLIPs' efficacy in targeting acidic environments.

Main Results:

  • Coating nanoparticles with pHLIPs improves targeting efficiency in acidic diseased tissues.
  • pHLIPs demonstrate promising results for nanotheranostics development.
  • This approach offers a pathway for more universal disease targeting.

Conclusions:

  • pHLIP-coated nanoparticles represent a significant advancement in targeted drug delivery.
  • This strategy holds great potential for treating cancer and other acid-associated diseases.
  • Further development of pHLIP-based nanotheranostics is warranted.